FDA Approves Stribild, New Combination Pill For HIV Treatment

The FDA has approved the use of Stribild, a new once-daily l HIV medication from Gilead, the makers of  HIV medications Atripla and Complera

Previous called “Quad,” it combines two previously approved HIV drugs and two new medications: elvitegravir, which interferes with one of the enzymes  HIV needs to multiply, and cobicistat, which prolongs the effects of elvitegravir.

“Through continued research and drug development, treatment for those infected with HIV has evolved from multi-pill regimens to single-pill regimens,” said the FDA’s Dr. Edward Cox. “New combination HIV drugs like Stribild help simplify treatment regimens.”

More than 1,400 adult patients not previously treated for HIV were evaluated in two double-blind clinical trials, with 88-90% of patients taking Stribild had an undetectable viral load, compared to the 87 % by those treated with Truvada plus atazanavir and ritonavir.

Like many HIV medications, Stribild still has several side effects, including the potential for in some patients nausea and diarrhea, kidney problems, and decreased bone-mineral density. Gilead says it will continue testing Stribild for its effects on women and children, drug resistance and drug interaction.

“Therapies that address the individual needs of patients are critical to enhancing adherence and increasing the potential for treatment success, and we are proud to introduce a new single tablet regimen for the healthcare and patient communities,” said Gilead CEO John C. Martin.

However, be forewarned: Stribild is enormously expensive, close to one-third  more than its competitors.

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  • The Real Mike in Asheville

    From 1997-2001 I was taking 56 pills/day — with 10 different taking times requiring an EXCEL spreadsheet (some twice day, some thrice, sone with food, some empty stomach).

    This is another great step forward — BUT, this is not a license to be reckless: the toll on the digestive track, kidneys and liver REQUIRE constant monitoring, and the fat redistribution is, while not as bad as KS legions, a horrible side-effect.

  • frshmn

    Atripla has been a single once a day pill available for years, outside of a slight possible gain in effectiveness (1-3%), this still has the bad side effects and isn’t closer to cure. I just feel real cynical that drug companies only seek to increase profits by lengthening patents and reliance on drugs rather than working on groundbreaking research.

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