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WATCH: Matthew McConaughey Undergoes Dramatic Emotional And Physical Transformation in “Dallas Buyers Club”

Remember those photos of scary-skinny Matthew McConaughey from last year? Well, it was all part of his DeNiro-esque transformation to star in Dallas Buyers Club. The sure-to-be-Oscar-nominated actor portrays real-life Texas cowboy Ron Woodroof, whose free-wheeling life was changed for good in 1985 when he was diagnosed as HIV-positive and informed by doctors he had only 30 days to live. Woodruff refused to accept the diagnosis and then began smuggling alternative drugs into America to help himself and other AIDS patients.

As the trailer suggests, McConaughey undergoes an emotional journey every bit as dramatic as his physical weight loss. Jared Leto, who also underwent a staggering slimming down, costars as a transsexual woman with HIV, who helps McConaughey’s character.

The fact-based film was directed by Jean-Marc Vallée, noted for the the award-winning gay-themed 2005 drama C.R.A.Z.Y. Dallas Buyers Club will open in L.A. and New York  November 1 followed by a wider theatrical release.